Russell Brand

E.B (voice)

James Marsden

Fred

Kaley Cuoco

Samantha O'Hare

Hank Azaria

Carlos / Phil (voice)

Elizabeth Perkins

Bonnie O'Hare

Gary Cole

Henry O'Hare

Hugh Laurie

E.B.'s Dad (voice)

David Hasselhoff

David Hasselhoff

Chelsea Handler

Mrs. Beck

Dustin Ybarra

Cody

Tiffany Espensen

Alex O'Hare

Jimmy Carter

Blind Boys of Alabama

Veronica Alicino

Waitress

Coleton Ray

Young Fred

Mark Riccardi

Security Guard

Greg Lewis

Performer

Hugh Hefner

Voice at Playboy Mansion (voice)

Rick Pasqualone

Utility Voice

Django Marsh

Young E.B. (voice)

Robbie Tucker

Kid#1 (uncredited)

Crystal the Monkey

Monkey (uncredited)