Ryan Reynolds

Detective Pikachu (voice)

Justice Smith

Tim Goodman

Kathryn Newton

Lucy Stevens

Bill Nighy

Howard Clifford

Ken Watanabe

Lieutenant Hide Yoshida

Chris Geere

Roger Clifford

Suki Waterhouse

Ms. Norman

Josette Simon

Grams

Alejandro De Mesa

Bartender

Rita Ora

Dr. Ann Laurent

Karan Soni

Jack

Max Fincham

Young Tim Goodman

Simone Ashley

Girlfriend

Edward Davis

Boyfriend

Diplo

DJ

Omar Chaparro

Sebastian

Ben Fox

Lead Cop

Kadiff Kirwan

Mayor

Ryoma Takeuchi

Male Pokémon Trainer

Rina Hoshino

Mewtwo (voice)

Kotaro Watanabe

Mewtwo (voice)

Ikue Otani

Pikachu (voice)

David Errigo Jr.

Cubone (voice)

Sean Chiplock

Roundhouse Arena Announcer / Train PA System (voice)

Rachael Lillis

Jigglypuff (voice)