Ioan Gruffudd

Reed Richards / Mr. Fantastic

Jessica Alba

Sue Richards / Invisible Woman

Chris Evans

Johnny Storm / Human Torch

Michael Chiklis

Ben Grimm / The Thing

Julian McMahon

Victor von Doom / Doctor Doom

Laurence Fishburne

Norrin Radd / Silver Surfer (voice)

Doug Jones

Norrin Radd / Silver Surfer

Kerry Washington

Alicia Masters

Andre Braugher

General Hager

Beau Garrett

Frankie Raye

Brian Posehn

Priest

Zach Grenier

James Sherman / Rafke

Kenneth Welsh

Dr. Jeff Wagner

Kevin McNulty

Baxter Building Doorman

Andy Stahl

Tailor

Debbie Timuss

Hot Party Girl #1

Moneca Delain

Hot Party Girl #2

Yan-Kay Crystal Lowe

Hot Party Girl #3

Vanessa Lachey

Johnny's Wedding Date

Stan Lee

Stan Lee - Rejected Wedding Guest

Gonzalo Menendez

Lieutenant

Giuliana Rancic

Entertainment Reporter

Lauren Sánchez Bezos

Fox News Reporter

Benjamin Ayres

Guard #1

Patricia Harras

Fan Four Receptionist

Fareed Abdelhak

Egyptian Tour Guide

Dawn Chubai

Anchorwoman

Alicia Thorgrimsson

New York Pedestrian

Valerie Tian

New York Teen Girl #1

Jeanna Haddow

New York Teen Girl #2

Ali Costigan

New York Teen Girl #3

Suzanne Ristic

Airline Woman

Michasha Armstrong

Wedding Security

Ulla Friis

Danish News Anchor (uncredited)

Nimet Kanji

Tourist in Egypt (uncredited)