Will Ferrell

Harold Crick

Maggie Gyllenhaal

Ana Pascal

Dustin Hoffman

Professor Jules Hilbert

Emma Thompson

Karen Eiffel

Queen Latifah

Penny Escher

Tony Hale

Dave

Tom Hulce

Dr. Cayly

Linda Hunt

Dr. Mittag-Leffler

Kristin Chenoweth

Book Channel Host

John M. Watson Sr.

TV Author

William Dick

IRS Co-Worker #1

Guy Massey

IRS Co-Worker #2

Martha Espinoza

IRS Co-Worker #3

T.J. Jagodowski

IRS Co-Worker #4

Peter Grosz

IRS Co-Worker #5

Tonray Ho

IRS Co-Worker #6

Herb Lichtenstein

IRS Co-Worker #7

Stacey Elaine Jackson

IRS Co-Worker #8

Ricky Adams

Young Boy

Christian Stolte

Young Boy's Father

Denise Hughes

Kronecker Bus Driver

Peggy Roeder

Polish Woman

Danny Rhodes

Bakery Employee #1

Linara Washington

Bakery Employee #2

Helen Young

Bakery Customer #1

David Pompeii

Bakery Customer #2

David Wiegers

Bakery Customer #3

Jarrett Sleeper

Bakery Customer #4

Larry Neumann Jr.

Homeless Man

John Mohrlein

Man with Hose

Bruce Jarchow

Commuter

Bradley Mott

Large Man on Bus

Karen Lloyd

Customer with Tan

Keith Kupferer

Demolition Foreman

Danny McCarthy

Demolition Crew #1

Tab Baker

Demolition Crew #2

Mark Buettner

Claw Operator

Christian Young

ER Doctor #1

Ray Kurut

ER Doctor #2

Michael Cook

ER Doctor #3

Arraon Skippa Hixson

Young Man Patient

Bryan Kelly

ER Orderly

Whitney Sneed

ER Nurse #1

Celeste Pechous

ER Nurse #2

Cheryl Lynn Bruce

Head ER Nurse

Chet Dubowski

Man in Tweed

Ora Jones

Banneker Press Receptionist

Jordan Keller

Grocer

Jordan Teplitz

Old Man on Phone

Ricardo Gutiérrez

Bus Company Manager

James Mazza

Irritated Man on Bus

Oscar Roxas

Another Man on Bus

Nadirah Bost

Accident Witness

Sandra Marquez

Accident Witness

Lacy Katherine Campbell

Accident Witness

Will Clinger

Accident Witness

Al Samuels

Accident Witness

Frank Caeti

Accident Witness

Andrew Rothenberg

Doctor Mercator

Rengin Altay

Nurse

Lucinda Kemp

Bus Operator #1

Donna Watkins

Bus Operator #2

Julia Heron

Animal Footage Voice Over (voice)

Lora Cain

Animal Footage Voice Over (voice)

Bob Papenbrook

Animal Footage Voice Over (voice)

Mike McColl

Animal Footage Voice Over (voice)

Nathan Adloff

Bakery Patron (uncredited)

Sia A. Moody

Nurse #3 (uncredited)

Eli Goodman

Augustus Chatman (uncredited)

Edy Cullen

Business Women (uncredited)

Tim Krueger

Business Man (uncredited)