Rick Moranis

Seymour Krelborn

Ellen Greene

Audrey

Vincent Gardenia

Mushnik

Levi Stubbs

Audrey II (voice)

Steve Martin

Orin Scrivello, D.D.S.

Tichina Arnold

Crystal

Michelle Weeks

Ronnette

Tisha Campbell

Chiffon

Jim Belushi

Patrick Martin

John Candy

Wink Wilkinson

Christopher Guest

The First Customer

Bill Murray

Arthur Denton

Stan Jones

Narrator (voice)

Bertice Reading

'Downtown' Old Woman

Ed Wiley

'Downtown' Bum #1

Alan Tilvern

'Downtown' Bum #2

John Scott Martin

'Downtown' Bum #3

Vincent Wong

Chinese Florist

Mak Wilson

Doo-Wop Street Singer

Danny Cunningham

Doo-Wop Street Singer

Danny John-Jules

Doo-Wop Street Singer

Gary Palmer

Doo-Wop Street Singer

Paul Swaby

Doo-Wop Street Singer

Mildred Shay

Second Customer

Melissa Wiltsie

Third Customer

Kevin Scott

Fourth Customer

Barbara Rosenblat

Fifth Customer

Adeen Fogle

Radio Station Assistant

Kelly Huntley

Audrey & Seymour's Kid

Paul Reynolds

Audrey & Seymour's Kid

Miriam Margolyes

Dental Nurse

Abbie Dabner

Boy Patient

Francis Dux

Second Patient

Peter Whitman

Patient on Ceiling

Heather Henson

Girl Patient

Judith Morse

Girl's Mother

Bob Sherman

Agent

Doreen Hermitage

'Life' Magazine Lady

Kerry Shale

Her Assistant

Robert Arden

Network Exec #1

Stephen Hoye

Network Exec #2

Bob Sessions

Network Exec #3

Michael Shannon

Television Reporter

Jill Goldston

Frantic Shopper (uncredited)