Michael J. Fox

Stuart Little (voice)

Geena Davis

Mrs. Little

Hugh Laurie

Mr. Little

Jonathan Lipnicki

George Little

Nathan Lane

Snowbell (voice)

Chazz Palminteri

Smokey (voice)

Steve Zahn

Monty (voice)

Jim Doughan

Lucky (voice) / Officer Allen

David Alan Grier

Red (voice)

Bruno Kirby

Mr. Stout (voice)

Jennifer Tilly

Mrs. Stout (voice)

Stan Freberg

Race Announcer (voice)

Jeffrey Jones

Uncle Crenshaw

Connie Ray

Aunt Tina

Allyce Beasley

Aunt Beatrice

Brian Doyle-Murray

Cousin Edgar

Estelle Getty

Grandma Estelle

Harold Gould

Grandpa Spencer

Patrick Thomas O'Brien

Uncle Stretch

Julia Sweeney

Mrs. Keeper

Dabney Coleman

Dr. Beechwood

Miles Marsico

Anton

Jon Polito

Officer Sherman

Joe Bays

Race Starter

Taylor Negron

Salesman

Kimmy Robertson

Race Spectator

Tannis Benedict

Hot Dog Vendor

Chuck Blechen

Skipper

Westleigh M. Styer

Skipper

Larry Goodhue

Boat Registrar

Joshua Paule

New Yorker (uncredited)